Jonathan Loaisiga pitched three-hit ball over five impressive innings to win his major league debut Patrick Kane Jersey , and the New York Yankees beat the Tampa Bay Rays 5-0 on Friday night.

Didi Gregorius homered off ex-Yankee Nathan Eovaldi, and Gary Sanchez broke out of a long slump with a three-run double in the eighth. Giancarlo Stanton had a sacrifice fly for New York, which improved the best record in the majors to 45-20.

Jonathan Holder, David Robertson, Dellin Betances and Adam Warren each worked an inning to finish the four-hitter.

Loaisiga (1-0) was called up from Double-A Trenton to fill in for injured starter Masahiro Tanaka. The 23-year-old righty, who walked only four batters in 45 minor league innings this year, struggled a little with his command, issuing four walks while striking out six.

Pitching against his former team, Eovaldi (1-2) allowed only two runs over the first seven innings until the Yankees chased him in the eighth. He was charged with five runs and eight hits in 7 1/3 innings during his first career outing against New York. He struck out five and walked one.

TWINS 6, INDIANS 3

CLEVELAND (AP) – Corey Kluber had a rare rocky performance, lasting just five innings and losing for the first time in seven starts as Kyle Gibson outpitched the Cy Young winner and Brian Dozier hit a two-run homer to lead Minnesota past Cleveland.

Kluber (10-3) allowed a homer on his fourth pitch of the game to Eddie Rosario and was pulled after throwing just 65 pitches by manager Terry Francona. It was the shortest outing this season for the All-Star, who came in 5-0 with a 0.76 ERA against AL Central teams and was riding several other impressive streaks.

Gibson (2-4) limited the Indians to one run and three hits in seven innings and got his first win since his season debut on March 31.

Yan Gomes homered in the ninth and the Indians closed to 6-3 before closer Fernando Rodney struck out Francisco Lindor with one on for his 15th save.

CUBS 13, CARDINALS 5

ST. LOUIS (AP) – Kris Bryant ended a 24-game homerless drought, the longest of his career Youth Jake McCabe Jersey , and Ian Happ and Kyle Schwarber also went deep as Chicago routed St. Louis.

Bryant drilled a two-run shot off an ineffective Michael Wacha for his first home run since May 14. The 2016 NL MVP capped a six-run fifth inning with an RBI single and added a sacrifice fly in the seventh. His four RBIs were a season high.

Jon Lester ran his scoreless streak to 17 innings before giving up a solo home run to Marcell Ozuna in the fourth as the Cubs won for the first time in four tries at Busch Stadium this season. Lester (8-2) allowed two runs in six innings to earn his fourth straight win.

Anthony Rizzo had three hits and Schwarber launched a three-run homer that traveled a projected 465 feet to straightaway center.

Wacha (8-2) gave up a career-high nine runs, eight earned, in a season-low four-plus innings.

Matt Carpenter homered and drove in two runs, but the Cardinals lost their third consecutive game.

DODGERS 3, GIANTS 2

LOS ANGELES (AP) – Ross Stripling pitched four-hit ball over 6 1/3 innings, Enrique Hernandez and Matt Kemp went deep to give the Dodgers a major league-leading 32 homers this month, and Los Angeles beat rival San Francisco in their series opener.

The Dodgers improved to 10-2 in June while sending the Giants to a 17th loss in their last 23 road games.

Stripling (6-1) extended his career-best winning streak to six games and is 4-0 at home this season. The right-hander gave up a two-run homer to Pablo Sandoval and had six strikeouts with no walks.

Kenley Jansen earned his 16th save.

Derek Holland (4-7) gave up three runs – two earned – in five innings. He struck out seven.

Earlier in the day, Kemp was suspended for one game and fined an undisclosed amount for his involvement in a scuffle with Texas catcher Robinson Chirinos on Wednesday. Kemp appealed the punishment, so he’s allowed to play until the process is completed.

MARINERS 7, RED SOX 6

SEATTLE (AP) – Denard Span’s pinch-hit double in the eighth inning drove in two runs, leading Seattle over Boston.

Span, hitting for Guillermo Heredia with one out, hit a liner into the right-field corner after Ryon Healy walked and Ben Gamel singled.

Rob Whalen pitched four shutout innings of relief for the Mariners. Ryan Cook (1-0) earned the win with a scoreless eighth and Edwin Diaz earned his major league-leading 26th save.

Matt Barnes (0-2) took the loss.

Xander Bogaerts hit a three-run homer as part of a six-run third that gave Boston a 6-3 lead, but a spectacular defensive play by Seattle second baseman Dee Gordon on a hard-hit ball up the middle by Bogaerts that ended the sixth kept Boston from adding another run.

ANGELS 8 Rick Nash Jersey , ATHLETICS 4

OAKLAND, Calif. (AP) – Ian Kinsler homered and drew a bases-loaded walk, Mike Trout had three hits and a sacrifice fly, and injury-plagued Los Angeles beat Oakland to snap a four-game skid.

Tyler Skaggs (6-4) struck out eight over seven strong innings, allowing no earned runs and seven hits with one walk. He improved to 3-0 with a 0.45 ERA in June.

The Angels placed four more players on the disabled list, bringing their total to a franchise-record 15 at one time and leaving just 12 members of the opening day roster active.

Jose Briceno and Jose Miguel Fernandez had RBI singles in the third as Los Angeles bounced back with a big offensive night after having lost four straight following a six-game winning streak. The Angels avoided matching their longest skid of the season.

Oakland starter Chris Bassitt (0-2) was done after four innings after he allowed six runs – only two earned on a s The old and new will be crossing paths at MetLife Stadium when the Jacksonville Jaguars open the season against the New York Giants.

The game will be the first for Jaguars executive vice president of football operations Tom Coughlin against the Giants, the team he led to two Super Bowl titles before resigning in January 2016 after a dozen seasons as coach.

It also will be Pat Shurmur's first regular-season NFL game as coach of the Giants, a team that has made the playoffs once (2016) since winning the Super Bowl in February 2012.

"Those who are around know the history," said Giants long snapper Zak DeOssie, who was a member of both Super Bowl teams. "We know Coughlin will have them fired up. It is the first game and everyone wants to get off on the right foot. I can't say it will be an extra motivator, but it's something we are aware of, and it doesn't chance our approach."

The Giants are just looking to play a lot better than last season. They went 3-13 and saw coach Ben McAdoo and general manager Jerry Reese get fired in early December.

Shurmur and new general manager Dave Gettleman have turned around much of the roster and they will get their first true peek at the new product this weekend in a very tough matchup.

The Jaguars (12-7) blew a 10-point fourth-quarter lead against the New England Patriots in the AFC title game in January. A trip to the Super Bowl was within their grasp.

"I think we've taking a good approach as a team, and as a group in the locker room of everybody that was a part of what happened last year so badly wants to get back to that AFC championship game and change that outcome," quarterback Blake Bortles said.

Bortles said the Jaguars aren't taking anything for granted.

"We've got to take every day Elias Lindholm Jersey , every week, every meeting of preparation as seriously as possible, and the rest will take care of itself and we'll end up back there again," he said.

Coughlin did not talk to the media in Jacksonville this week, but coach Doug Marrone said Coughlin has not changed his approach with the return to New York.

"We know we've got a tough road ahead of us and we know we've got a tough game on the road opening day up in New York," Marrone said. "They'll be fired up and ready to go."

Here are some other things to watch:

BARKLEY-BECKHAM: There are no two players the Giants' faithful wants to see more than running back Saquon Barkley and three-time Pro Bowl receiver Odell Beckham Jr. Barkley was the second overall pick in the draft and has the talent and explosiveness to give the Giants a strong running game for the first time since 2011. Beckham missed most of last season after breaking his left ankle in early October. He did not play in the preseason, but has looked good with Eli Manning in practice and owns the richest contract for a wide receiver in NFL history.

JAGS DEFENSE: Jacksonville is loaded on defense with six returning Pro Bowlers: cornerbacks A.J. Bouye and Jalen Ramsey, linemen Calais Campbell, Malik Jackson and Yannick Ngakoue, and linebacker Telvin Smith Sr. The Jaguars were ranked No. 2 in the league last season, with Ramsey and Campbell making the All-Pro Team.

"When you have the kind of confidence we have, when you believe that we can be as good as we can, you can't wait to get there and just try to show it play after play," Campbell said.

SECONDARY WOES: New York has three veteran starters in the secondary Ryan Dzingel Jersey , cornerbacks Eli Apple and newcomer Janoris Jenkins, and star safety Landon Collins. Untested Curtis Riley is the free safety. There is uncertainty about the nickel and dime backs with Donte Deayon, B.W. Webb and Michael Thomas in the mix. Depth is an issue. The team signed Antonio Hamilton, Mike Jordan and Kamrin Moore this week.

ON THE WIDE SIDE: Bortles has to find a new go-to receiver with Marqise Lee out for the year with a knee injury. Keelan Cole, second on the team last season with 42 catches for 748 yards and three touchdowns, is starting along with veteran Donte Moncrief, who was signed as a free agent. Dede Westbrook is the third receiver for a team ranked No. 1 in rushing. The problem is the Giants are good against the run and that puts pressure on the wide receivers to step up.

O-LINE: The Giants spent almost $80 million to rebuild their line. Left tackle Nate Solder and right guard Patrick Omameh signed as free agents. Left guard Will Hernandez was drafted. Ereck Flowers was moved to right tackle from the left side, and Jon Halapio took over at center. The line protected well in the preseason. There were not a lot of holes for the running backs.

ELI-RAMSEY: Watch to see if Manning throws at Ramsey. The Jags cornerback slighted the two-time Super Bowl MVP in the offseason, refusing to say Manning is good while adding Beckham is the one who really makes the Giants go.

AP Sports Writer Mark Long contributed to this story.

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